MoNALISA Team

The team "Modified Nucleic Acids, Lipids and Innovative Synthetic Approaches" focuses its activities on the chirality and the issues related to the biologically active molecules, their synthesis, their recognition and biological activity.

• Nucleic acids functionalized by catalytic groups are designed, prepared and used for stereoselective chemical transformations or targeted degradation of proteins.
• Bioinspired acetylenic lipids with chiral alkynylcarbinol motifs are developed for their antitumor and antimycobacterial properties.
• The search for pharmacological chaperones of glucosidases in the context of lysosomal storage diseases is pursued thanks to the development of original sphingolipid mimics of the iminosugar type. These pharmacophores are introduced on multivalent supports of the dendrimer type.

• These three axes are linked by two transversal skills using, on the one hand, ionic liquids as media for the catalysis or the structuring of nucleic acids and, on the other hand, streptocyanines for the development of fluorescent probes based on bioactive lipids labeling or the functionalization of aptamer fragments for the detection of secondary DNA structures.

Chirality, biomimetics, organic synthesis, modified nucleic acids, acetylenic lipids, iminosugar, sphingolipids, streptocyanines, ionic liquids.
 

• Yves Génisson is laboratory manager. He is member of the managment board of Integrated Screening Plateform of Toulouse (PICT), of the streering committee of Toulouse Insitut of Chemistry (ICT) and of the boards of the doctoral school and Sciences de la Matière of Université Paul Sabatier - Toulouse 3.