2024
Grosjean, E.; Rizet, J.; Arabi Aliabadi, S.; Azéma-Despeyroux, J.; Hoffmann, P.; Lherbet, C.
5,5′-Selenobis(1-Benzyl-2-Oxo-1,2-Dihydropyridine-4-Carbaldehyde).
MolBank 2024, M1919. https://www.mdpi.com/1422-8599/2024/4/M1919
Abboub, F.; Amari, M.; Fodili, M.; Hoffmann, P.
One-Pot Synthesis of Substituted Benzimidazole-Pyrimidine Derivative.
Russ. J. Gen. Chem. 2024, 94, 2671 https://link.springer.com/article/10.1134/S1070363224100128
Saffon-Merceron, N.; Lherbet, C.; Hoffmann, P.
Synthesis and Characterization of N-Nitroso-3-morpholinosydnonimine as NO Radical Donor.
MolBank 2024, M1886. https://www.mdpi.com/1422-8599/2024/4/M1886
Hoffmann, P.; Azéma-Despeyroux, J.; Goncalves, F.; Stamilla, A.; Saffon-Merceron, N.; Rodriguez, F.; Degiacomi, G.; Pasca, M. R.; Lherbet, C.
Imidazoquinoline Derivatives as Potential Inhibitors of InhA Enzyme and Mycobacterium tuberculosis.
Molecules 2024, 29, 3076. doi.org/10.3390/molecules29133076
Venugopala, K. N.; Chandrashekharappa, S.; Deb, P. K.; Al-Shar'i, N. A.; Pillay, M.; Tiwari, P.; Chopra, D.; Borah, P.; Tamhaev, R.; Mourey, L.; Lherbet, C.; Aldhubiab, B. E.; Tratrat, C.; Attimarad, M.; Nair, A. B.; Sreeharsha, N.; Mailavaram, R. P.; Venugopala, R.; Mohanlall, V.; Morsy, M. A.
Identification of potent indolizine derivatives against Mycobacterial tuberculosis: In vitro anti-TB properties, in silico target validation, molecular docking and dynamics studies.
Int. J. Biol. Macromol. 2024, 274, 133285. doi.org/10.1016/j.ijbiomac.2024.133285
Derdour, M. ; Belkacem, Z. ; Belkheiri, N. ; Karef, S. ; Amari, M. ; Saffon-Merceron, N. ; Rodriguez, F. ; Lherbet, C. ; Fodili, M. ; Hoffmann, P.
Preparation and InhA inhibitory properties of novel dehydroacetic acid-derived thiazoles.
Synthetic Commun. 2024, 54, 962-972. doi.org/10.1080/00397911.2024.2361790
Birgül, S. İ. D. ; Kumari, J. ; Tamhaev, R.; Mourey, L. ; Lherbet, C. ; Sriram, D. ; Akdemir, A. ; Küçükgüzel , I.
In silico design, synthesis and antitubercular activity of novel 2-acylhydrazono-5-arylmethylene-4-thiazolidinones as enoyl-acyl carrier protein reductase inhibitors.
J. Biomol. Struct. Dyn. 2024, 1-19. doi.org/10.1080/07391102.2024.2319678
Remy, C.; Danoun, S.; Delample, M.; Morris, C.; Gilard, V.; Balayssac, S.
Characterization of fatty acid forms using benchtop NMR in omega-3 oil supplements
Magn. Reson. Chem. 2024, 62, 328. doi.org/10.1002/mrc.5398
Tamhaev, R. ; Grosjean, E. ; Ahamed, H.; Chebaiki, M. ; Rodriguez, F. ; Recchia, D. ; Degiacomi, G. ; Pasca, M.R. ; Maveyraud, L. ; Mourey, L. ; Lherbet, C.
Exploring the plasticity of the InhA substrate-binding site using new diaryl ether inhibitors.
Bioorg. Chem. 2024, 143,107032. doi.org/10.1016/j.bioorg.2023.107032.
Pujol, C. ; Danoun, S. ; Biasini, G. ; Retailleau, E. ; Masson, J. ; Balayssac, S. ; Gilard, V.
Benchtop NMR Coupled with Chemometrics: A Workflow for Unveiling Hidden Drug Ingredients in Honey-Based Supplements.
Molecules, 2024, 29, 2086. doi.org/10.3390/molecules29092086
2023
Duhail, T. ; Messaoudi, S. ; Dagousset, G. ; Marrot, J. ; André-Barrès, C. ; Magnier, E. ; Anselmi, E.
Benzodithiazoles-Sulfoximines: Preparation, Properties and Reactivities as Radical Perfluoroalkylating Agents.
Advanced Synthesis & Catalysis, 2023 (doi.org/10.1002/adsc.202300553)
Chebaiki, M.; Delfourne, E.; Tamhaev, R.; Danoun, S.; Rodriguez, F.; Hoffmann, P.; Grosjean, E.; Goncalves, F.; Azéma-Despeyroux, J.; Pal, A.; Kordulakova, J.; Preuilh, N.; Britton, S.; Constant, P.; Marrakchi, H.; Maveyraud, L.; Mourey, L.; Lherbet, C.
Discovery of new diaryl ether inhibitors against Mycobacterium tuberculosis targeting the minor portal of InhA
European Journal of Medicinal Chemistry, 2023 (in press doi.org/10.1016/j.ejmech.2023.115646)
Bremond, E.; Boggio-Pasqua, M.; Leygue, N.; Fodili, M.; Hoffmann, P.; Saffon-Merceron, N.; Métivier, R.; Fery-Forgues, S.
ESIPT-active cinnamoyl pyrones are bright solid-state emitters: Revisited theoretical approach and experimental study.
Dyes and Pigments, 2023, 211, 111046.
Danoun, S.; Balayssac, S.; Gilard, V.; Martino, R.; Malet-Martino, M.
Quality evaluation of berberine food supplements with high-field and compact 1H NMR spectrometers.
J. Pharm. Biomed. Anal. 2023, 223, 115161. doi.org/10.1016/j.jpba.2022.115161
Balayssac, S.; Danoun, S.; Gilard, V.; Martino, R.; Malet-Martino, M.
The POWER saga from 2007 to 2022: An example of a sexual enhancement dietary supplement tainted by different adulterants and still on the market.
J. Pharm. Biomed. Anal. 2023, 227, 115283. doi.org/10.1016/j.jpba.2023.115283
Remy, C.; Danoun, S.; Delample, M.; Morris, C.; Gilard, V.; Balayssac, S.
Characterisation of fatty acid forms using benchtop NMR in omega-3 oil supplements
Magn. Reson. Chem. 2023, 62, 328. doi.org/10.1002/mrc.5398
2022
Aslan, E.K.; Han, M.I.; Krishna, V.S.; Tamhaev, R.; Dengiz, C.; Doğan, S.D.; Lherbet, C.; Mourey, L.; Tønjum, T.; Gündüz, M.G.
Isoniazid linked to sulfonate esters via hydrazone functionality: Design, synthesis, and evaluation of antitubercular activity.
Pharmaceuticals 2022, 15, 1301.
Vanucci-Bacque, C.; Andre-Barres, C.; Saffon-Merceron, N.; Bedos-Belval, F.
Unexpected boratranes: BBr3 mediated synthesis and mechanistic insights.
Tetrahedron 2022, 124, 133019.
Hoffmann, P.; Lherbet, C.; Fabing, I.; Barthélémy, M.-C.; Borjon-Piron, Y.; Laurent, C.; Vigroux, A.
A Mesoporous metal-organic framework used to sustainably release copper(II) into reducing aqueous media to promote the CuAAC click reaction.
RSC Advances 2022, 12, 26825-26833.
Castro, I.; Andre-Barres, C.; Fabre, N.; Massou, S.; Sauvain, M.; Castillo Pareja, D.; Jullian, V.
Cordiasecosides G-J, 9,10-Seco-29-norcycloartane glycosides isolated from Cordia lutea and their antibacterial activities
Fitoterapia 2022, 158, 105172
Tapera, M. ; Kekeçmuhammed, H. ; Sahin, K. ; Krishna, V. S. ; Lherbet, C. ; Homberset, H. ; Chebaiki, M. ; Tonjum, T. ; Mourey, L. ; Zorlu, Y. ; Durdagi, S. ; Saripinar, E.
Synthesis, characterization and molecular modeling studies of thiourea derivatives bearing aminoguanidine moiety.
J. Mol. Struct. 2022, 1270, 133899.
Atici, R. K.; Doğan, S.D.; Gündüz, M.G.; Krishna, V. S.; Chebaiki, M.; Homberset, H.; Lherbet, C.; Mourey, L.; Tonjum, T.
Urea derivatives carrying a thiophenylthiazole moiety: Design, synthesis and evaluation of antitubercular and InhA inhibitory activities.
Drug Dev. Res. 2022, 83, 1292–1304
2021
Gonnet, L.; Chamayou, A.; Andre-Barres, C.; Micheau, J.-C.; Guidetti, B.; Sato, T.; Baron, M.; Baltas, M.; Calvet, R.
Elucidation of the Diels-Alder Reaction Kinetics between Diphenylfulvene and Maleimide by Mechanochemistry and in Solution.
ACS Sustainable Chemistry & Engineering 2021, 9, 4453-4462.
Levy, T.; Marchand, L.; Stroobant, V.; Pilotte, L.; Van den Eynde, B.; Rodriguez, F.; Delfourne, E.
IDO1 and TDO Inhibitory Evaluation of Analogues of the Marine Pyrroloiminoquinone Alkaloids: Wakayin and Tsitsikammamines.
Bioorg. Med. Chem. 2021, 40, 127910.
Farjallah, A.; Chiarelli, L. R.; Forbak, M.; Degiacomi, G.; Danel, M.; Goncalves, F.; Carayon, Seguin, C.; Fumagalli, M.; Zahorszka, M.; Vega, E.; Abid, S.; Grzegorzewicz, A.; Jackson, M.; Peixoto, A.; Kordulakova, J.; Pasca, M. R.; Lherbet, C.; Chassaing, S.
A Coumarin-Based Analogue of Thiacetazone as Dual Covalent Inhibitor and Potential Fluorescent Label of HadA in Mycobacterium tuberculosis.
ACS Infect. Dis. 2021, 7, 552-565.
Carayon, C.; Andre-Barres, C.; Leygue, N.; Saffon-Merceron, N.; Boggio-Pasqua, M.; Fery-Forgues, S.
The role of the synthetic chromophore of GFP in generating polymorphism-dependent on/off photoluminescence.
Dyes and Pigments, 2021, 187, 109119.
Bourgeade-Delmas, S.; André-Barrès, C.; Lucas, J.; Trinel, M.; Castillo Pareja, D.; Jullian, V.
Bioactive Isocedrenes from Perezia multiflora.
Planta Medica 2021, 87, 201-208.
Fernández de Luco, J.; Recio-Balsells, A. I.; Ghiano, G.; Bortolotti, A.; Belardinelli, J. M.; Liu, N.; Hoffmann, P.; Lherbet, C.; Tonge, P. J.; Tekwani, B.; Morbidoni, H. R.; Labadie, G. R.
Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents.
RSC Med Chem, 2021,12, 120-128.
2020
Pepe, D. A.; Toumpa, D.; Andre-Barres, C.; Menendez, C.; Mouray, E.; Baltas, M.; Grellier, P.; Papaioannou, D.; Athanassopoulos, C. M.
Synthesis of Novel G Factor or Chloroquine-Artemisinin Hybrids and Conjugates with Potent Antiplasmodial Activity.
ACS Med. Chem. Lett. 2020, 11, 921-927.
Gonnet, L.; Andre-Barres, C.; Guidetti, B.; Chamayou, A.; Menendez, C.; Baron, M.; Calvet, R.; Baltas, M.
Study of the two steps and one-pot two-step mechanochemical synthesis of annulated 1,2,4-triazoles.
ACS Sustainaible Chem. Eng. 2020, 8, 3114-3125.
Doğan, S. D.; Gündüz, M. G.; Doğan, H.; Lherbet, C.; Krishna, V. S.; Sriram, D.
Design and synthesis of thiourea-based derivatives as Mycobacterium tuberculosis growth and enoyl acyl carrier protein reductase (InhA) inhibitors.
Eur. J. Med. Chem. 2020, 199, 112402.
Doğan, H.; Doğan, S. D.; Gündüz, M. G.; Krishna, V. S.; Lherbet, C.; Sriram, D.; Şahin, O.; Sarıpınar, E.
Discovery of hydrazone containing thiadiazoles as Mycobacterium tuberculosis growth and enoyl acyl carrier protein reductase (InhA) inhibitors.
Eur. J. Med. Chem. 2020, 188, 112035.
Rodriguez, F.; Saffon, N.; Sammartino, J. C.; Degiacomi, G.; Pasca, M. R.; Lherbet, C.
First triclosan-based macrocyclic inhibitors of InhA enzyme.
Bioorg. Chem. 2020, 95, 103498.
2019
Saffon-Merceron, N.; Vigroux, A.; Hoffmann, P.
Crystal structure of a 2D coordination framework of formula [Zn(NDC)(DEF)].
Acta Cryst. 2019, E75, 1759-1762.
Joshi, S. D.; Kumar, P. S. R.; Patil, S.; Vijayakumar, M.; Kulkarni, V. H. ; Nadagouda, M. N.; Badiger, A. M. ; Lherbet, C.; Aminabhavi, T. M.
Chemical synthesis, molecular modeling and pharmacophore mapping of new pyrrole derivatives as inhibitors of InhA enzyme and Mycobacterium tuberculosis growth.
Med. Chem. Res. 2019, 28, 1838-1863.
Shaikh, M. S.; Kanhed, A. M.; Chandrasekaran, B.; Palkar, M. B.; Agrawal, N.; Lherbet, C.; Hampannavar, G. A.; Karpoormath, R.
Discovery of novel N-methyl carbazole tethered rhodanine derivatives as direct inhibitors of Mycobacterium tuberculosis InhA. Bioorg.
Med. Chem. Lett. 2019, 29, 2338-2344.
Pinzi, L.; Lherbet, C.; Baltas, M.; Pellati, F.; Rastelli, G.
In Silico Repositioning of Cannabigerol as a Novel Inhibitor of the Enoyl Acyl Carrier Protein (ACP) Reductase (InhA).
Molecules 2019, 24, E2567.
André-Barrès, C. ; Lalevée, J. ; Anselmi, E. ; Dagousset, G.; Magnier, E.; Gigmes, D.; Tuccio, B.
Méthode du spin trapping : la RPE pour la détection d’intermédiaires réactionnels.
L'Actualité Chimique, 2019, 25-29.
Dehoux, C.; Castellan, T.; Enel, M.; André-Barrès, C.; Mirval, S. ; Becq, F. ; Ballereau, S.; Génisson, Y.
Transalpinecine and Analogues: First Total Synthesis, Stereochemical Revision and Biological Evaluation.
Eur. J. Org. Chem., 2019, 19, 1830-1834
2018
Joshi, S. D.; Dixit, S. R.; Basha, J.; Kulkarni, V. H.; Aminabhavi, T. M.; Nadagouda, M. N.; Lherbet, C.
Pharmacophore mapping, molecular docking, chemical synthesis of some novel pyrrolyl benzamide derivatives and evaluation of their inhibitory activity against enoyl-ACP reductase (InhA) and Mycobacterium tuberculosis.
Bioorg Chem. 2018, 81, 440-453.
Chollet, A.; Maveyraud, L.; Lherbet, C.; Bernardes-Genisson, V.
An overview on crystal structures of InhA protein: apo-form, in complex with its natural ligands and inhibitors.
Eur. J. Med. Chem. 2018, 146, 318-343 (Review).
Suresh, A.; Agnieszka, N.; Ewa, A.-K.; Alvala, M.; Lherbet, C.; Chandra Sekhar, K. V. G.
Design, synthesis of 9H-fluorenone based 1,2,3-triazole analogues as Mycobacterium tuberculosis InhA inhibitors.
Chem. Biol. Drug Des. 2018, 91, 1078-1086.
Moulkrere, B. R.; Orena, B. S.; Mori, G.; Saffon-Merceron, N.; Rodriguez, F.; Lherbet, C.; Nadji, B.; Mohamed, A.; Hoffmann, P.; Fodili, M.
Evaluation of heteroatom-rich derivatives as antitubercular agents with InhA inhibition properties.
Med. Chem. Res. 2018, 27, 308-320.
Belkheiri, N.; Belkacem, Z.; Derdour, M.; Mechrouch, F.; Bachar, R. M.; Fodili, M.; Amari, M.; Hoffmann P.
Synthesis of benzimidazole-cyclohexanone derivatives.
J. Fundam. Appl. Sci. 2018, 10, 213-22.
Hamza, K.; Touati, A.; Ait-Yahia, A.; Baltas, M.; André-Barrès, C.; Moulay, S.
Effect of the nature of surfactant on the reactivity of C-N diphenylnitrone towards acrylonitrile in different microemulsion systems.
Chemistry Journal of Moldova; General, Industrial and Ecological Chemistry 2018, 13, 82-88
2017
Anicat, A.; André-Barrès, C.; Delfourne, E.
New reaction of formation of the fused tricyclic bispyrroloquinone ring system.
Tetrahedron Lett. 2017, 58, 342-345.
Joshi, S. D.; More, U. A.; Dixit, S. R.; Balmi, S. M.; Kulkarni, B. G.; Ullagaddi, G.; Lherbet, C.; Aminabhavi, T. M.
Chemical synthesis and in silico molecular modeling of novel pyrrolylbenzohydrazide derivatives: their biological evaluation against enoyl ACP reductase (InhA) and Mycobacterium tuberculosis.
Bioorg. Chem. 2017, 75, 181-200.
Oliveira, P. F. M.; Guidetti, B.; Chamayou, A.; André-Barrès, C.; Madacki, J.; Kordulaková, J. Mori, G.; Orena, B. S.; Chiarelli, L. R.; Pasca, M. R.; Lherbet, C.; Carayon, C.; Massou, S.; Baron, M.; Baltas, M.
Mechanochemical Synthesis and Biological Evaluation of Novel Isoniazid Derivatives with Potent Antitubercular Activity.
Molecules 2017, 22, 1457-1484.
Faille, A.; Gavalda, S.; Slama, N., Lherbet, C.; Guillet, V.; Laval, F.; Quémard, A.; Mourey, L.; Pedelacq, J.-D.
Insights into substrate modification by dehydratases from typeI fatty acid and polyketide synthases.
J. Mol. Biol. 2017, 429, 1554-1569.
Martino, R.; Menendez, C.; Balayssac, S.; Martins, N.; Lherbet, C.; Couderc, F.; Gilard, V.; Malet-Martino, M.
A revisited structure for nitrosoprodenafil from NMR, mass spectrometry, X-ray and hydrolysis data.
J. Pharm. Biomed. Anal. 2017, 135, 31-49.
Joshi, S. D.; Dixit, S. R.; Kulkarni, V. H.; Lherbet, C.; Nadagouda, M.; Aminabhavi, T. M.
Synthesis, biological evaluation and in silico molecular modeling of pyrrolyl benzohydrazide derivatives as enoyl ACP reductase inhibitors.
Eur. J. Med. Chem. 2017, 126, 286-297.